In-vivo integration of soft neural probes through high-resolution printing of liquid electronics on the cranium
Young-Geun Park, Yong Won Kwon, Chin Su Koh, Enji Kim, Dong Ha Lee, Sumin Kim, Jongmin Mun, Yeon-Mi Hong, Sanghoon Lee, Ju-Young Kim, Jae-Hyun Lee, Hyun Ho Jung, Jinwoo Cheon, Jin Woo Chang, and Jang-Ung Park
Nature Communications, Feb 2024
To enable high-quality neural recordings in freely moving animals, our materials science team developed a liquid metal–based neural probe that can be directly printed onto the brain, along with elastic electronic circuits. To validate the fidelity of the signals recorded by this neural probe, we statistically assessed the long-term stability of signal clustering and examined the correlations between micro-scale neuronal activity and macro-level brain dynamics during mouse behavioral experiments involving visual and motor stimuli.